Best Kratom for Pain – How it Works, Dosage & Top Strains

The Best Kratom Strains For Pain – a Comprehensive Guide

Does your body feel tight due to the amount of stress you’re dealing with? Do you feel like a tightly coiled spring also dealing with persistent discomfort and pain? If this resonates with you, know that you are far from being the only one. As the famous philosopher, writer, and poet Friedrich Nietzsche once said, ‘To live is to suffer…”

Of course, life is a wonderful blessing, but in today’s fast-paced modern world, more of us are ‘feeling the pain’ as our body’s try to keep up with the demands of daily life.

That’s where Kratom comes in.

For thousands of years, humans have sought out natural remedies and homeopathic means to soothe their mind, body, and soul, with one such plant standing head and shoulders above the rest.

For centuries, Mitragyna Speciosa, an evergreen tree native to Southeast Asia known as Kratom, has offered the people of Indonesia and around the world a soothing remedy for aches and pains.

People seeking out alternatives to alcohol, cannabis, or pharmaceuticals may find that Kratom offers the analgesic effects they desire, all without the harsh side effects and risks associated with other options.

In this guide we explore the best Kratom strains for pain, helping you find the perfect strains to ease your body into a state of blissful comfort.

Pain: A Silent Epidemic that Kratom May be Able to Tame

Most of us are suffering from some type of ache, pain, strain, or soreness. From strenuous blue-collar jobs, to hunching over an office chair in a cubicle, or simply tending to the needs of rambunctious children, we put our bodies through a lot.

According to a Georgetown University study, nearly 65 million Americans report a recent episode back pain and aches, with nearly 8% of the entire population suffering from chronic back issues.1

Similarly, the Centers for Disease Control (CDC), reports that over 20% of the US adult population suffers from chronic pain of all types, with nearly 8% suffering from debilitating pain.2

Add to that the general wear and tear we put on our bodies in our daily lives, from work to sports, and it’s no wonder so many people seek out ways to relieve strain and pain, including various Kratom strains.

For those seeking natural alternatives to aid with relief from daily living, Kratom may provide both the physical and psychological effects necessary to enjoy life to the fullest.

The Best Kratom for Pain – Understanding Strains

Kratom is a plant-based product made entirely from the leaves of the Mitragyna Speciosa tree. It contains no additives or harsh chemicals and is an all-natural botanical that has been used for hundreds of years for its analgesic (pain-reducing) abilities.

The leaves of the Mitragyna Speciosa tree are carefully hand-picked throughout the tree’s growing cycles, after which they are dried and processed under temperature and light-controlled conditions.

While all strains of Kratom share some basic characteristics, nuances, and effects can vary widely from one strain to another.

The most common strains of Kratom include:

  • Red
  • White
  • Green; and
  • Yellow

Each strain is grown using time-honored traditions passed down by generational farmers throughout Indonesia. The location of the farms can have a dramatic impact on the final product, attributable to biodiversity, soil composition, and weather conditions.

Similarly, each strain is unique, made from leaves harvested at differing stages throughout the growth cycle, and processed in specific ways that result in various concentrations and profiles of naturally occurring alkaloids.3

It is these alkaloids and their respective concentrations that result in Kratom’s effects.4

Kratom For Pain Relief: How Kratom Strains Work to Reduce Pain?

Prior to choosing a Kratom strain for pain, it’s important to understand how and why Kratom produces its pain-relieving effects when consumed. This background on how Kratom works to alleviate pain can help you better determine which Kratom strain is ideal for your own needs.

For example, some strains that tackle pain lean towards a deeply relaxing and sedative effect, while others are soothing yet uplifting and mood-enhancing, making them more ideal for social occasions rather than crashing on the couch after a long day’s work.

What makes each strain better or worse for pain? The concentration and combination of plant alkaloids found in the Kratom leaves of each strain are responsible for each strain’s independently unique effects. With more than 40 identified alkaloids,5 there can be a significant difference between strains of Kratom, making it difficult for consumers to find the right one to help manage chronic pain.

How Does Kratom Work For Pain?

As of March 2023, only two clinical trials have been conducted to study the effects of Kratom on human participants, so information about exactly how Kratom works to manage or reduce pain in people is lacking.6 However, numerous preclinical in-vivo (living animals) and in-vitro (tests performed on specific cells or tissues from an animal, or a model system) studies have been performed to better understand the pharmacodynamics and pharmacokinetics of bioactive alkaloids found in Kratom, as well as how it exerts its effects in the brain and body.

Further, we can draw on anecdotal reports from consumers, as well as descriptive and case studies gathered from the tens of millions of Kratom consumers worldwide. The American Kratom Association estimates there are 10-16 million consumers in the U.S. alone.6

Let’s take a closer look at how Kratom helps to alleviate pain.

1. Stimulation of Opioid Receptors – There are three main opioid receptor types involved in pain: Mu, kappa, and delta. When activated, all three receptors send signals to alleviate pain, but the mu receptor is the most powerful. Mu receptors also have antitussive effects when activated and they contribute the most to the euphoria and sedation associated with opioid drugs. Unfortunately, they can also cause respiratory depression, constipation, nausea, itching, and addiction. Kappa receptors agonists relieve pain, cause euphoria, and are sedating, but to a lesser degree than mu receptors. Unlike the mu receptor, they can have negative effects on mood like irritability or depression. Activation of the kappa receptor also causes respiratory depression. Delta receptors are the only ones that when activated have purely analgesic effects, without mood alteration or visceral changes.7

The alkaloids in Kratom have different effects on all three receptors. For example, 7α-hydroxymitragynine is a partial mu agonist with strong binding activity and a delta and kappa antagonist. It is about 13 times stronger than morphine, which is a full mu agonist. Speciociliatine and mitragynine have closely related structures, and both are partial mu agonists with moderate binding affinity and no action at the other receptors. Speciociliatine is equivalent in strength to morphine, while mitragynine is far weaker.8

2. Inhibition of COX-2 – an inflammatory enzyme9

3. Muscle Relaxant Properties – reducing muscle fiber and joint tension10

4. Euphoria and Mood – Similar to cannabis, Kratom indirectly reduces pain through its ability to produce euphoria and a state of soothing well-being and uplifted mood. This acts as a type of distraction, with consumers reporting the pain exists but is ‘background noise’ and doesn’t bother them nearly as much.11

We’ll explore these mechanisms in greater detail later on. For now, let’s look at which Kratom strains are best for pain relief.

The Best Kratom for Pain Relief in 2023

Red Strains – the Best Vein for Physical Soothing

Arguably the best Kratom strain for soothing chronic aches and pains are red strains. Red Kratom is well-known for exerting a strong relaxing, soothing, relieving, and sedating effect.

More than that, red vein Kratom is euphoric, mood-enhancing, and analgesic (pain-relieving).

Red vein Kratom is made from Mitragyna Speciosa leaves picked further along in the plant’s growth cycle (when the veins turn a deep red in color). The red veins, from which the strain gets its namesake, is indicative of a high concentration of Mitragynine and 7α-hydroxymitragynine.12 These two prominent alkaloids have potent analgesic and muscle-relaxing properties.

After the first growth season, the tree often endures a period of drought, during which these alkaloids build up and concentrate in the tips of the leaves. When the next rainy season hits, these alkaloids are deposited into the veins of the leaves, turning them red and indicating they are ready to use in making red-veined Kratom.

Accounting for up to 66% of the alkaloid content in red Kratom strains, Mitragynine has been clinically and/or scientifically proven to be:12

  • Analgesic
  • Adrenergic
  • Antitussive
  • Antidiarrheal
  • And act as a possible psychedelic (5-HT2A antagonist)

The primary effects are a deeply soothing and relaxed state of being that many find optimal at the end of a long day, before bed, or when they want to unwind.

Related: THESE Are The Most POTENT Kratom Strains

Other Alkaloids in Red Vein Kratom that May Contribute to a Soothing Effect

Paynantheine – May act as a muscle relaxer.13 Muscle tension is a major contributing factor for pain and discomfort. According to the journal of Current Top Behavioral Neuroscience, between 11-24% of the world’s population suffers from chronic pain due to muscle tension and soreness, and most people experience it at some point in their lives.14

Speciogynine – Similar to Paynantheine, Speciogynine may act as a smooth muscle relaxer to relieve muscle-related pain and discomfort. Its mechanism of action is still being researched.13

Speciociliatine – May aid in inhibiting acetylcholine release from presynaptic nerves through a mechanism other than opioid receptor stimulation.15 Acetylcholine is a neurotransmitter that (in part) helps keeps muscles in balance. Muscle contraction is initiated when signals from the brain travel to motor neurons that control the muscle. When a motor neuron receives the message it releases acetylcholine into the neuromuscular junction. Acetylcholine binds to its receptors on the muscle membrane, which triggers a complex sequence of events resulting in muscle fiber contraction. Speciociliatine’s influence on inhibiting acetylcholine is able to reduce contraction of muscle fibers, alleviating tension and potentially reducing pain.

The Best Red Kratom Strains for Pain

1. Red Maeng Da Kratom

Out of all Kratom strains available on the market, none is as potent as Red Maeng Da Kratom. Originating in Thailand, Maeng Da Kratom is now cultivated throughout Southeast Asia, where it is known for its highly concentrated alkaloid content. In fact, the Thai word ‘Maeng Da’ can be roughly translated in English to ‘pimp grade’, meaning strong.

What makes Red Maeng Da Kratom so potent is an alkaloid profile that isn’t just dense, but rich with Mitragynine and 7α-hydroxymitragynine. These compounds have been scientifically proven to be the two most biologically potent alkaloids derived from Kratom, with pain-relieving abilities compared to and even exceeding the effects of morphine.16

Together, these alkaloids work in synergy with over 40 other minor alkaloids to produce effects ranging from analgesic (pain relieving), to sedative, euphoric, and uplifting.

Red Maeng Da Kratom Effects:

  • Analgesia / pain-relief
  • Euphoria
  • Stress relief
  • Muscle relaxing
  • Mood enhancing
  • Sedative
  • Calming
  • Soothing

2. Red Bali

Red Bali Kratom is one of the most popular strains of Kratom. Cultivated on the island of Bali, Red Bali is well known for its relaxed, euphoric effects, as well as for its analgesic properties. Red Bali is also one of the most sedating strains of Kratom, making it great for unwinding after work, chilling on weekends, or before bed.

The effects of Red Bali Kratom can be both stimulating and sedating, depending on the dose (more on dosing later). Stimulating effects include increased energy, alertness, and concentration. Sedating effects include increased relaxation, calmness, and a sense of peace and well-being. Red Bali Kratom is often used by consumers in an effort to relieve symptoms of anxiety, depression, and insomnia, as well as for pain management.

Red Bali Kratom is available in a variety of forms, including Kratom powder, capsules, and tea. It can also be bought as an extract or tincture, and as one of the more readily available strains, is also quite affordable.

When taking Red Bali Kratom, it is important to start with a low dose and increase gradually as needed. The effects of Red Bali Kratom can last for several hours.

Red Bali Effects:

  • Pain relief
  • Improved mood
  • Relief of stress
  • Muscle relaxing
  • Sedation
  • Sense of calm and peace
  • Soothing

3. Red Borneo

Red Borneo Kratom is known for its strong soothing effects, which make it a popular choice for those seeking relief from anxiety, stress, or pain. Red Borneo Kratom is also known for its ability to improve mood and to promote relaxation.

Red Borneo Kratom is typically harvested from Mitragyna Speciosa trees cultivated on the island nation of Borneo, where the diverse ecosystem and weather aid in helping the tree produce a robust alkaloid profile conducive to pain relief.

The effects of red Borneo Kratom can vary depending on the dose. At lower doses, red Borneo Kratom produces mildly energizing effects, including increased alertness and focus. At higher doses, red Borneo Kratom produces calming euphoria, sedative effects, and pain and muscle relief.

Red Borneo Effects:

  • Analgesic pain relief
  • Mood enhancement
  • Muscle soothing
  • Tension-reducing
  • Euphoria
  • Reduced stress
  • Sedation (at higher doses)
  • Mild stimulation (loser doses)

Green Strains – the Best Vein for Dealing with Both the Physical and Mental Aspects of Pain

Red Kratom strains are the best when it comes to tackling the physical symptoms of pain, but they have one major downside: many users find them too sedating, leaving them lethargic, tired, or in need of a nap. As you can imagine, this is anything but ideal when it comes to tackling the responsibilities of the day. Be it for work, play, or social activities, you can’t be productive and enthusiastic if you are walking around all day with “brain fog.”

That’s why reds are best for nighttime use, after a long day at work, or on weekends when you can relax and unwind, and don’t have to accomplish anything too mentally or physically demanding.

But what about the rest of the time? That’s where Green Kratom veins come in. Green-veined Kratom is notable for its balanced effects, embodying the stimulating properties of white Kratom, but also offering much of the same soothing, muscle-relaxing, and pain-relieving properties of red strains.

In many ways, Green vein Kratom is the “best of both worlds”, offering a middle ground for consumers. It’s ideal for managing pain and taming stress and anxiety, with enough of a mental boost that you are able to carry out your usual daily routine.

Green Strains – Soothing for the Mind and the Body

Green Kratom is made from leaves picked during the first growth cycle. At this stage of growth, the ‘veins’ of the leaves are light to dark green, hence ‘green’ in the name. This color and level of maturation indicate the presence of certain alkaloids and concentrations of those alkaloids, the combination of which gives green strains its unique effects. The relaxing, soothing, sedative red strains are in juxtaposition with the stimulating, energizing, uplifting white strains. Green strains fall in the middle of the spectrum, offering the consumer a balanced experience with benefits from each end.

While white and red strains represent polar opposites of the Kratom spectrum, with whites being typically energetic and uplifting, and reds being sedative and relaxing, greens embody the best of both worlds.

Primary Alkaloids Responsible for Green Kratom’s Soothing Effects

Similar to all varieties of Kratom, 7α -hydroxymitragynine and mitragynine are the most prevalent alkaloids in the plant. The concentration and balance of these is such that green strains tend to have a mellowing effect that is relaxing and uplifting, making it a favorite for social occasions, creative activities such as making craft and art, and can even be helpful for a normal workday. It’s an often used strain of Kratom for daytime activities when you need soothing pain relief without feeling so drowsy and relaxed that you can’t get anything done.

There are still healthy doses of both 7α-hydroxymitragynine and mitragynine in this strain which is why green-veined Kratom also offers moderate pain relief in addition to its mental stress-relieving and soothing capabilities.

Other Notable Alkaloids that Make Green Kratom Great for Relief

Some green varieties of Kratom, such as Green Malay, have been shown in the lab to contain significant levels of an alkaloid called Speciofoline, a proven analgesic capable of relieving pain, as well as possessing antitussive abilities. Speciofoline was seen to have so much potential that Smith Kline (of Glaxo Smith Kline), a leading global pharmaceutical R&D and drug company, patented the alkaloid back in 1964. More than 40 years later, this powerful alkaloid gained renewed interest from the University of Mississippi and the University of Massachusetts Medical School, both of which jointly patented Speciofoline for use in opiate withdrawal.

The Best Green Kratom Strains for Pain

1. Green Maeng Da Kratom

Similar to Red Maeng Da, the green variety of Maeng Da is considered the strongest of green-vein Kratom. This potent strain is well-balanced, but with a more pronounced effect in all categories, including euphoria, mood, and muscle/pain relief.

Despite being well-balanced, being neither too sedative nor too stimulating, Green Maeng Da Kratom’s effects are still dose-dependent. Higher doses will still lean more sedative, while lower doses will still trend more stimulating and energizing.

Green Maeng Da Kratom Effects:

  • Euphoric
  • Increased alertness (at lower doses)
  • Anxiety-reducing
  • Soothing
  • Mood-enhancing
  • Pain relieving
  • Relaxing

2. Green Malay

Green Malay, also known as Green Malaysian, is a strain of Kratom grown and processed in Malaysia.

Among this strain’s primary alkaloids is Mitragynine, the main biologically active alkaloid in Green Malay, and is responsible for most of its effects. 7α-hydroxymitragynine comes in second as the most prominent alkaloid in this strain, along with minor alkaloids including paynanthine, speciogynine, and several others. Together, these work to provide relaxing effects that affect the body and mind, working synergistically together to aid with muscle relaxation, pain relief, mood improvement, and more.

Green Malay Effects:

  • Better mood
  • Relaxation
  • Pain relief
  • Muscle relaxing
  • Mild euphoria

3. Green Bali

If you are searching for a potent, yet relaxing strain of Kratom, look no further than green Bali Kratom. This particular strain originates from the island of Bali in Indonesia where it is cultivated in rich tropical soil, producing a unique alkaloid profile that many find useful for daytime pain relief, mood enhancement, and more. This strain gets its name from the green veins of the leaves it is made from, as well as the island it is grown on.

Green Bali Kratom is a reliable strain that can be used for a variety of purposes. It is one of the most popular strains available and is known for its ability to produce both stimulating and sedating effects depending on the dose taken.

Many people use it to help with anxiety, stress relief, as a mild stimulant (at lower doses) to help with focus and concentration and it is also a popular strain for pain relief.

Green Bali Kratom is typically commercially available in powder form. It can also be found in capsules or tablets. Like all Kratom, the Kratom powder can be mixed with water or juice and taken orally. It can also be brewed into a tea.

Green Bali Effects:

  • Stimulating at lower doses
  • Sedating at higher doses
  • Overall better sense of wellbeing
  • Reduced stress and anxious feelings
  • Lower pain
  • Body and mind relaxation
  • Mild euphoria

How Does Kratom Work For Pain?

Earlier we briefly discussed how different strains of Kratom work for pain. Here, we’ll dive even further into the science to help you understand what makes Kratom so useful for relief.

Opioid Receptors

The same receptors affected by opioids are those that Kratom also interacts with. According to the Frontiers in Pharmacology journal, the alkaloids in Kratom have been shown to produce analgesic (pain relieving) effects by way of mediating mammalian opioid receptors.

Specifically, Mitragynine and 7α-hydroxymitragynine work in an agonist or antagonistic manner on traditional opioid receptors such as µ (MOR), δ (DOR), and κ (KOR). These and the other alkaloids present in Kratom work on the same receptor system as morphine does, but each alkaloid has different activity at each opioid receptor. The unique combination of alkaloids in each type of Kratom relieves pain and induces relaxation a lot like morphine, but to a lesser degree AND with a limited side effects profile and level of toxicity as compared to prescribed opioid medications.

According to widespread scientific research, mitragynine has been identified as the predominant alkaloid in Kratom, and accounts for much of its analgesic properties. Kratom and its various alkaloids have been shown to be strong candidates for pain reduction in numerous comprehensive preclinical studies and by the accounts of millions of users. More clinical trials involving human participants should be performed to study how it works in humans and confirm its validity as a therapeutic agent for pain relief.

COX-2 and Inflammation

A study in the Journal of Medical Hypothesis claims that the mechanisms of all pain syndromes are related at least partially to the activation of inflammatory mediators and their responses. This study contends that the goal of pain management should be focused on the suppression or inhibition of the production of primary inflammatory mediators, inhibition of downstream components in major inflammatory pathways, or interruption of the incoming or outgoing pain signals in sensory neurons involved.17

As described by Mayo Clinic, inflammation can be helpful as part of the body’s natural healing mechanisms, but it can also be quite damaging, causing a host of adverse symptoms and effects including but not limited to:

  • An increased risk of developing chronic diseases such as cancer, diabetes, heart disease, arthritis, and more
  • Reduced quality of life
  • Pain
  • Discomfort or tenderness
  • And more…

One such biological pathway involved in inflammatory responses is the cyclo-oxygenase-2 (COX-2) enzyme and along with it, expression of prostaglandin E2 (PGE2).

A study in the Journal of Ethnopharmacology looked at how Mitragynine may influence the expression of COX-2 and PGE2 production. The findings showed that Mitragynine suppressed PGE2 production by way of inhibition of COX-2, and concluded that Mitragynine could be useful for the treatment of inflammation, a major source and contributor of pain.18

Muscle Relaxant

Muscle tension is often a considerable contributor to muscle and joint pain, which is associated with significant discomfort, reduced mobility, increased risk of accidents/injury, and reduced quality of life.

One of the ways Kratom may help to alleviate pain associated with muscle and joints is by acting as a skeletal muscle relaxant.

There is scientific evidence that supports Kratom’s ability to relax muscles. Research on the pharmacological properties of Kratom found that the vast majority of effects are mediated by opioid receptors (as noted earlier), but also through calcium channels, and expression of CREB protein and cAMP. Among a vast range of other processes, calcium channels are highly involved in muscle fiber contractility, with mediation of these channels often resulting in muscle relaxation.10

Kratom offers anti-inflammatory, antidepressant, and antinociceptive properties. Its antinociceptive properties may also have a strong influence on reducing pain and pain perception when the body is exposed to extreme temperatures, sensory system overload, toxic chemicals or stimuli, and mechanical injury (such as muscle soreness from overworking or overexerting).10

Kratom’s Effect on the Brain

Among the most highly concentrated alkaloids in Kratom are 7α-hydroxymitragynine and Mitragynine. Studies have revealed an interesting fact about these alkaloids. Both are able to engage our body’s naturally occurring opioid receptors. These receptors, present in the brain, are capable of inducing sedation, pleasure, and pain relief (much like opioids).

In addition to these two major alkaloids, there are over 40 other alkaloids that may exert their own effects and/or work synergistically with Mitragynine and 7α-hydroxymitragynine to create a soothing and relaxing effect.

Notably, Kratom increases serotonin and dopamine (the ‘feel good’ neurotransmitter). Dopamine, among other biological processes, regulates our pleasure center and rewards system. By increasing dopamine, Kratom can increase feelings of contentment, happiness, and pleasure (euphoria).19 Indirectly, these effects can limit or reduce the perception of pain.

Additional Clinical and Scientific Studies Demonstrating Kratom’s Ability to Manage Pain

YALE JOURNAL OF BIOLOGICAL MEDICINE

26 males were studied for their pain tolerance in a randomized, double-blind research. 1 hour after taking Kratom, pain tolerance increased significantly. The placebo group’s pain tolerance was unaffected.

JOURNAL OF DRUG AND ALCOHOL DEPENDENCE

In September 2017, 2867 current and 157 past Kratom users were anonymously surveyed by the American Kratom Association and its associated social media sites. The study found that the most commonly reported reason for Kratom use was for the relief of pain, endorsed by 48% of respondents. Other reasons were to relieve psychological stress (22%), for energy and focus (10%), or help with opioid withdrawals (10%). Over 90% of consumers agreed that Kratom was helpful for pain relief. Only 13% of trial participants had negative effects, and only 0.8% quit taking the herb.

ANIMAL STUDIES ON KRATOM AND PAIN

A whole library of in-vitro and in-vivo research indicates potential for using Kratom and its alkaloids to relieve pain.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, JOURNAL OF BEHAVIORAL PHARMACOLOGY

Many studies demonstrate that the alkaloids mitragynine and 7α-hydroxymitragynine are responsible for the pain-alleviating effects of Kratom. The primary effects are mediated by the opioid receptor system, but other mechanisms have been demonstrated to be complementary. A study in rats found that 7α-hydroxymitragynine works to relieve pain primarily through opioid receptor agonism, but mitragynine has a more complicated mechanism that partially involves opioid receptors. Further animal studies have implicated multiple contributing factors. One such study in rats concluded that mitragynine exerted its analgesic effects via TRPV1 and anti-inflammatory pathways. 9,20

JOURNAL OF MEDICINAL CHEMISTRY

This comprehensive study showed that Kratom alkaloids mitragynine, 7α-hydroxymitragynine, and speciociliatine relied on the opioid receptor system to mediate anti-nociceptive effects in rats. 7α-hydroxymitragynine had the strongest effects, followed by speciociliatine and then mitragynine. In-vitro pharmacokinetic and pharmacodynamic experiments demonstrated that the analgesic ability of each alkaloid was related to its binding affinity at mu, delta, and kappa opioid receptors.21

JOURNAL OF THE FEDERATION OF AMERICAN SOCIETIES FOR EXPERIMENTAL BIOLOGY

Twenty-five Kratom alkaloids were evaluated for binding affinities and other pharmacological parameters at mu, delta, and kappa opiate receptors. Many were found to have partial agonism at the mu receptor, with 7α-hydroxymitragynine, corynoxine A > epiallo-isopaynantheine, isospeciofoline, speciociliatine, corynoxine B > mitragynine, 3-epicorynoxine B > paynantheine and speciogynine. 7α-hydroxymitragynine was found to have the greatest analgesic effect in rats.22

What’s The Best Dose of Kratom For Pain?

One of the most popular uses of Kratom is for managing pain. Kratom is nature’s answer to pain management and its benefits are becoming more and more well-known. Kratom has been used for centuries in Southeast Asia for its analgesic (pain-relieving) properties. In fact, the traditional uses of Kratom are numerous and Pain is one of the more popular reasons that people turn to this amazing plant.

The best dose of Kratom for pain will vary depending on the individual. Factors such as weight, tolerance, and the severity of pain (among other factors) will all play a role in determining the perfect dose.

For most people, a moderate dose of 2-4 grams is all that is needed for mild pain relief, however, others find that a dose between 5-7 grams really does the trick. That said, anyone new to Kratom should start with a lower dose to gauge their tolerance before ramping up or tapering down as needed.

It is important to note that there is NO established clinical dose of Kratom, and that Kratom’s effects vary based on the dose taken. Because of this, and due to everyone’s unique physiology, you may need to experiment with different dosing protocols to find what works best for you.

And remember, lower doses tend to be more stimulating (like a cup of coffee), whereas moderate to higher doses tend to be more relaxing and sedative.

Related: How to Dose Kratom the Right Way

Summary – Finding the Best Kratom for Pain

Some Closing Thoughts on Kratom’s Effectiveness as a Pain Reliever

There are numerous claims that Kratom is beneficial for your health, but few are as scientifically and clinically supported as its ability to alleviate pain.

There are more than 40 different alkaloids that do the work, and many of them work by targeting the same receptors that drugs like OxyContin and Dilaudid use to relieve pain. That’s why Kratom has such powerful analgesic effects, exceeding the most potent over-the-counter pain relievers and giving prescription drugs a run for their money.

Despite the fact that Kratom, like other painkillers, may be addictive, it has been shown again and time again to be far less harmful than the alternatives.

If you’ve been suffering from pain in silence or are looking for a natural alternative to help you manage discomfort, Kratom might just be what you’ve been looking for.

Consider shopping with one of our highly vetted vendors to ensure purity and potency. These vendors third-party test each batch to ensure customers get what’s on the label and nothing else.

References

1.      Back Pain. Health Policy Institute.  Published 2000. Updated 2000.

2.      Carla E. Zelaya PD, James M. Dahlhamer, Ph.D., Jacqueline W. Lucas, M.P.H., and Eric M. Connor, B.S. Chronic Pain and High-impact Chronic Pain Among U.S. Adults, 2019. CDC. NCHS Data Brief No. 390 Web site. https://www.cdc.gov/nchs/products/databriefs/db390.htm. Published 2020. Updated Nov 4 2020.

3.      Smith KE, Sharma A, Grundmann O, McCurdy CR. Kratom Alkaloids: A Blueprint? ACS Chem Neurosci. 2023;14(2):195-197.

4.      Sinou V, Fiot J, Taudon N, et al. High-performance liquid chromatographic method for the quantification of Mitragyna inermis alkaloids in order to perform pharmacokinetic studies. J Sep Sci. 2010;33(12):1863-1869.

5.      Adkins JE, Boyer EW, McCurdy CR. Mitragyna speciosa, a psychoactive tree from Southeast Asia with opioid activity. Curr Top Med Chem. 2011;11(9):1165-1175.

6.      Li X, Ndungu P, Taneja SB, et al. An evaluation of adverse drug reactions and outcomes attributed to kratom in the US Food and Drug Administration Adverse Event Reporting System (FAERS) from January 2004 through September 2021. Clinical and Translational Science. 2023.

7.      Trescot AM, Datta S, Lee M, Hansen H. Opioid pharmacology. Pain Physician. 2008;11(2 Suppl):S133-153.

8.      Surash Ramanathan FL, Nelson J.Y. Chear, Siti R. Yusof, Vikneswaran Murugaiyah, Lance R. McMahon, Christopher R. McCurdy,. Kratom (Mitragyna speciosa Korth.): A description on the ethnobotany, alkaloid chemistry, and neuropharmacology. In: Atta-ur-Rahman, ed. Studies in Natural Products Chemistry. Vol Volume 69. Elsevier; 2021:195-225.

9.      Mat NH, Bakar SNS, Murugaiyah V, Chawarski MC, Hassan Z. Analgesic effects of main indole alkaloid of kratom, mitragynine in acute pain animal model. Behavioural Brain Research. 2023;439.

10.    Fluyau D, Revadigar N. Biochemical Benefits, Diagnosis, and Clinical Risks Evaluation of Kratom. Front Psychiatry. 2017;8:62.

11.    Hartley C, Bulloch M, Penzak SR. Clinical Pharmacology of the Dietary Supplement Kratom (Mitragyna speciosa). The Journal of Clinical Pharmacology. 2022;62(5):577-593.

12.    Chittrakarn S, Penjamras P, Keawpradub N. Quantitative analysis of mitragynine, codeine, caffeine, chlorpheniramine and phenylephrine in a kratom (Mitragyna speciosa Korth.) cocktail using high-performance liquid chromatography. Forensic Science International. 2012;217(1-3):81-86.

13.    Hassan Z, Muzaimi M, Navaratnam V, et al. From Kratom to mitragynine and its derivatives: physiological and behavioural effects related to use, abuse, and addiction. Neurosci Biobehav Rev. 2013;37(2):138-151.

14.    Gregory NS, Sluka KA. Anatomical and Physiological Factors Contributing to Chronic Muscle Pain. In: Behavioral Neurobiology of Chronic Pain.2014:327-348.

15.    Prozialeck WC, Jivan JK, Andurkar SV. Pharmacology of kratom: an emerging botanical agent with stimulant, analgesic and opioid-like effects. J Am Osteopath Assoc. 2012;112(12):792-799.

16.    Fowble KL, Musah RA. A validated method for the quantification of mitragynine in sixteen commercially available Kratom (Mitragyna speciosa) products. Forensic Sci Int. 2019;299:195-202.

17.    Omoigui S. The biochemical origin of pain: the origin of all pain is inflammation and the inflammatory response. Part 2 of 3 – inflammatory profile of pain syndromes. Med Hypotheses. 2007;69(6):1169-1178.

18.    Utar Z, Majid MI, Adenan MI, Jamil MF, Lan TM. Mitragynine inhibits the COX-2 mRNA expression and prostaglandin E(2) production induced by lipopolysaccharide in RAW264.7 macrophage cells. J Ethnopharmacol. 2011;136(1):75-82.

19.    Effendy MA, Yunusa S, Zain ZM, Hassan Z. Real time monitoring of dopamine release evoked by mitragynine (Kratom): An insight through electrochemical sensor. Neurosci Lett. 2021;763:136183.

20.    Obeng S, Wilkerson JL, Leon F, et al. Pharmacological Comparison of Mitragynine and 7-Hydroxymitragynine: In Vitro Affinity and Efficacy for mu-Opioid Receptor and Opioid-Like Behavioral Effects in Rats. J Pharmacol Exp Ther. 2021;376(3):410-427.

21.    Obeng S, Kamble SH, Reeves ME, et al. Investigation of the Adrenergic and Opioid Binding Affinities, Metabolic Stability, Plasma Protein Binding Properties, and Functional Effects of Selected Indole-Based Kratom Alkaloids. J Med Chem. 2020;63(1):433-439.

22.    Hemby SE, McIntosh S, Graf TN, et al. Pharmacological characterization of kratom alkaloids at opiate receptors: binding affinities, in vitro and in vivo functional assessments. The FASEB Journal. 2022;36(S1).

Written by Daniel Recardo

Founder of Kratom IQ; a self-improvement junkie and Kratom enthusiast. I started this website in 2015 to help people avoid the common pitfalls and mistakes with Mitragyna Speciosa, and ultimately get the most out of this amazing plant. Learn More...

Further Reading

Freshly picked Kratom
Resources
For those of you new to Kratom (also known as Mitragyna Speciosa) or just new to this website, Kratom IQ, I thought I'd put together this Quick Start Guide.
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An introduction to Kratom (Mitragyna Speciosa) including what it is, where it's from, how to take it and some of it's potential effects.
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The Best Kratom for Sleep and Relaxation, and Strains for Combating Fatigue Caused by Little Sleep. Dosage, How to Use and What You Need to Know.
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Does Kratom Make You High? What Does it Do Exactly? Here are Effects of Kratom Associated With Different Strains and Doses.

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